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Explain the problems associated with the genetic disorder Tay-Sachs. A. This lysosome is responsible for clearing out the fatty acid proteins that build up in the cells of the brain. The build up begins to interfere with proper brain development and growth. This leads to malfunctions in vision, movement, hearing, and overall mental development. The impairment leads to blindness, seizures, and paralysis.

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Tay-Sachs is an autosomal recessive diso...

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How are Fragile X syndrome and Huntington disease similar?


A) Both exhibit a late onset in life.
B) Both are trinucleotide repeat expansion disorders.
C) Both affect the muscles and lead to eventual paralysis.
D) Both cause autism.
E) Both are found only in males.

F) A) and B)
G) None of the above

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The definition of a multifactorial trait is one in which more than one set of alleles is involved in which the environment plays no role.

A) True
B) False

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Even though sickle-cell disease is inherited as an autosomal recessive disorder, the heterozygote can express some variation of the recessive phenotype.

A) True
B) False

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True

If a mother is a carrier for color-blindness and her husband is not, which of the following children are most likely?


A) 1 normal daughter, 1 carrier daughter, 1 normal son, and 1 color-blind son
B) 2 normal daughters, 1 normal son, and 1 color-blind son
C) 2 carrier daughters, 1 normal son, and 1 color-blind son
D) 1 normal daughter, 1 carrier daughter, and 2 normal sons
E) 1 normal daughter, 1 carrier daughter, and 2 color-blind sons

F) D) and E)
G) All of the above

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Which of the following traits would not be considered multifactorial?


A) alcoholism
B) suicide risk
C) cleft lip/palate
D) diabetes
E) ABO blood type

F) B) and D)
G) B) and C)

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Which of the following represents a dihybrid cross?


A) ff x ff
B) Gg x gg
C) AAbb x Aabb
D) AAbb x aaBB
E) Ss x ss

F) B) and D)
G) B) and C)

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Which of the following is a dominant allele?


A) A
B) a
C) AA
D) ab
E) Ab

F) D) and E)
G) A) and B)

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Which of the following disorders is caused by a defect in the production of an elastic connective tissue protein called fibrillin?


A) cystic fibrosis
B) Tay-Sachs disease
C) Marfan syndrome
D) Huntington disease
E) sickle-cell disease

F) All of the above
G) A) and E)

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Which of the following is not a characteristic of an X-linked recessive disorder pedigree?


A) An affected son can have normal parents.
B) If a female has the trait, her father must also have it.
C) The characteristic often skips a generation.
D) More females than males are affected.
E) If a woman has the characteristic, all of her sons will have it.

F) B) and C)
G) C) and E)

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D

Which of the following genotypes is heterozygous?


A) Aa
B) Ab
C) aB
D) ab
E) aa

F) B) and C)
G) A) and D)

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In a dihybrid cross, in which both parents are heterozygous for both traits, what is the probability that the offspring will exhibit both of the dominant phenotypes?


A) 1/16.
B) 3/16.
C) 6/16.
D) 9/16.
E) 1.

F) B) and E)
G) B) and D)

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Of the three possible alleles for the ABO blood type, each individual can have how many?


A) one
B) two
C) three
D) none
E) half an allele

F) C) and E)
G) A) and B)

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List the genotypic ratios of the cross between a man with O blood type and a woman who is heterozygous B blood type.

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Man's genotype is ii. The woma...

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Which of the following traits is an X-linked recessive disorder?


A) Color blindness
B) Tay-Sachs
C) Cystic fibrosis
D) Sickle-cell disease
E) Marfan syndrome

F) A) and E)
G) B) and E)

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Probability calculations in which the word "or" is used involve the product rule.

A) True
B) False

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If you want to know the probability that tossing two coins will result in a particular outcome (two heads, for example) , you use the


A) product rule.
B) sum rule.
C) punnett rule.
D) Bergman's rule.
E) genetics rule.

F) A) and D)
G) A) and C)

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A

Which of the following is not a characteristic of an autosomal recessive disorder pedigree?


A) Heterozygotes have an affected phenotype.
B) Affected children can have unaffected parents.
C) Two affected parents will always have affected children.
D) Both males and females are affected with equal frequency.
E) Affected individuals with homozygous unaffected mates will have unaffected children.

F) A) and B)
G) A) and C)

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In a cross of a homozygous dominant parent and a homozygous recessive parent, what is the ratio of offspring that will exhibit the recessive phenotype?


A) 0.
B) 1/4.
C) 1/2.
D) 3/4.
E) 1.

F) B) and E)
G) C) and D)

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Which of the following genetic disorders is due to a lack of the lysosome enzyme hex A?


A) cystic fibrosis
B) Tay-Sachs disease
C) Huntington disease
D) sickle-cell disease
E) Marfan syndrome

F) A) and C)
G) C) and E)

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