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DNA polymerase requires a(n)


A) amino acid primer.
B) lipid primer.
C) hydrophilic primer.
D) DNA primer.
E) RNA primer.

F) All of the above
G) B) and C)

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DNA consists of two antiparallel strands of nucleotide chains held together by


A) peptide bonds.
B) polar covalent bonds.
C) ionic bonds.
D) hydrogen bonds.
E) complementary base pairing bonds.

F) B) and D)
G) All of the above

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D

In which of the following cells might you expect to find the highest level of telomerase?


A) muscle cells
B) oocytes
C) neurons
D) cells that replenish the lining of the gut

E) None of the above
F) A) and B)

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The two strands in the DNA molecule contain nitrogen bases which are


A) identical.
B) parallel.
C) complementary.
D) the same in all species.
E) exact copies of the protein they makE.

F) A) and B)
G) B) and E)

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Which of the following DNA replicating enzymes is responsible for unwinding the double helix of DNA?


A) DNA primase
B) DNA polymerase I
C) DNA helicase
D) DNA gyrase
E) DNA ligase

F) A) and E)
G) None of the above

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The chemical bonds that stabilize the complimentary nitrogen bases into a double helix are


A) nitrogen bonds.
B) hydrogen bonds.
C) hydrophobic bonds.
D) peptide bonds.
E) phosphodiester bonds.

F) All of the above
G) B) and D)

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The chemical bond connecting one nucleotide with the next one along the nucleic acid chain is called a


A) C = C bond.
B) hydrogen bond.
C) hydrophobic bond.
D) phosphodiester bonD.
E) peptide bond.

F) C) and E)
G) A) and E)

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Avery and his coworkers showed the "transforming principle" as


A) protein.
B) polysaccharide.
C) DNA.
D) RNA.
E) lipid.

F) A) and E)
G) None of the above

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C

Endonucleases and exonucleases are enzymes that can remove nucleotides.An endonuclease _______ while an exonuclease ______________.


A) chews away at the 5' end of DNA;cuts DNA internally
B) chews away at a 3' end of DNA;cuts the 5' end of DNA
C) cuts DNA internally;chews away at the end of DNA
D) adds nucleotides internally to DNA;adds nucleotides on the 3' and 5' ends of DNA

E) A) and B)
F) A) and C)

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C

X-ray crystallography of purified DNA fibers shows a pattern that suggests a helical structure,and provides dimensions of that structure.


A) Hershey and Chase
B) Chargaff
C) Franklin
D) Watson and Crick

E) A) and B)
F) A) and C)

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The replisome has two main subcomponents.They are


A) the replication folk and the sliding clamp subunit.
B) the primosome and the sliding clamp subunit.
C) the replication folk and the DNA pol III enzymes.
D) the DNA pol III enzymes and the sliding clamp subunits.
E) the primosome and a complex of two DNA pol III enzymes.

F) A) and C)
G) B) and C)

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When nonvirulent bacteria were mixed with dead virulent bacteria,Griffith unexpectedly found that the injected mice died.He explained this behavior by suggesting the nonvirulent strain of bacteria as being


A) activated.
B) transformed.
C) translated.
D) transcribeD.
E) expressed.

F) C) and D)
G) B) and D)

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You are asked to give a classroom demonstration of DNA supercoiling.To do so,you take two different colored pieces of rubber tubing,twist them very tightly and excessively around each other and join the ends of the tubing appropriately.Next,you remove the supercoiling by breaking one strand and unwinding it.In this demonstration,the breaking and winding simulates the action of


A) exonucleases.
B) polymerases.
C) helicases.
D) topoisomerases.

E) A) and B)
F) A) and C)

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The site of the opening of the DNA strands where active replication occurs is referred to as the


A) replication folk.
B) replisome.
C) primosome.
D) DNA pol III complex of two enzymes.
E) sliding clamp subunit.

F) All of the above
G) A) and C)

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Which of the following is not a component of nucleic acids?


A) organic nitrogen bases
B) sugar
C) phosphate
D) protein

E) A) and B)
F) A) and C)

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You are asked to participate in a clinical trial for a new drug that can activate telomerase.Which of the following is a likely risk of such a drug?


A) decreased capacity for tissue repair
B) increased vulnerability to cancer
C) premature aging
D) decreased telomere length

E) None of the above
F) A) and B)

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Avery,MacLeod,and McCarty's experiments revealed that the transforming principle had all of the following properties except


A) its activity was destroyed by treatment with proteases.
B) its activity was unaffected by RNA-digesting enzymes.
C) its activity was unaffected by lipid extraction.
D) its activity was destroyed by treatment with DNA endonucleases.

E) A) and C)
F) B) and D)

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The lagging strand is replicated with stretches of Okazaki fragments and that is why its synthesis is considered to be


A) discontinuous.
B) continuous.
C) primed.
D) never stopping.
E) semiconservativE.

F) A) and D)
G) A) and C)

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The enzyme that catalyzes the synthesis of new DNA molecules is called


A) DNA ligase.
B) DNA polymerase.
C) DNA gyrase.
D) DNA helicase.
E) DNA endonucleasE.

F) C) and D)
G) None of the above

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When injected into a bacterial cell by T2 virus particles,the material that specifies the new generation of viruses is DNA and not protein.


A) Hershey and Chase
B) Chargaff
C) Franklin
D) Watson and Crick

E) B) and C)
F) None of the above

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