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Protein synthesis proceeds by the ribosome


A) alternating between many chains.
B) moving three nucleotides at a time on the mRNA.
C) attaching amino acids in a random fashion.
D) selecting the tRNA molecule that fits.
E) attaching amino acids to the growing chain without charged tRNAs.

F) None of the above
G) A) and D)

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What is the likely consequence of a mutation in a point mutation affecting a branch point?


A) no effect,since branch points are located in introns
B) a splicing error
C) failure of snRNAs to recognize 5' end of intron
D) no exon shuffling

E) B) and D)
F) A) and C)

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How would a large chromosomal inversion affect the transcription of internal genes?


A) The inversion may have no effect on transcription.
B) The genes would not be expressed because they would now be oriented in the wrong direction.
C) The genes would be now expressed in the 3' to 5' direction.
D) It would lead to a tandem duplication.

E) C) and D)
F) A) and D)

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Given the sentence "THE FAT CAT ATE THE RED RAT," which of the following would represent a frameshift mutation?


A) THE FAT CAT ATE THE RED RAT
B) THE CAT ATE THE RED RAT
C) THE FAC ATA TET HER EDR AT
D) THE FAT RAT ATE THE RED RAT

E) All of the above
F) B) and D)

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In eukaryotic cells,mRNA is made as a copy of the DNA coding information in the


A) cytoplasm.
B) mitochondria.
C) ER.
D) nucleus.
E) plasma membranE.

F) B) and E)
G) A) and B)

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The different components of the protein synthesizing machinery include all of the following except


A) mRNA.
B) tRNA.
C) ribosomes.
D) amino acids.
E) RNA polymerasE.

F) A) and B)
G) A) and C)

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Because nucleic acid sequence information is changed into amino acid sequence information,polypeptide synthesis is known as


A) breaking the code.
B) decoding.
C) transcription.
D) translocation.
E) translation.

F) A) and D)
G) B) and C)

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The transfer of information from DNA to mRNA is referred to as


A) transcription.
B) translation.
C) transformation.
D) transference.
E) translocation.

F) B) and C)
G) A) and E)

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The many different functions and behaviors of living organisms are essentially based on the performance of their cells.The cells' performance in turn is dependent upon the


A) production of many varieties of polypeptides and proteins.
B) production of correct membranes.
C) proper conformation for water in the cells.
D) production of steroids and hormones.
E) ability to reproducE.

F) D) and E)
G) C) and E)

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You are conducting a genetic screen to isolate nutritional mutants in yeast.Specifically,you want to isolate a histidine leucine double mutant.You start with a wild type yeast strain and mutagenize it with a UV light.Which of the following outlines the remaining steps for isolating such a mutant?


A) Grow mutagenized yeast on rich mediA.Grow yeast on minimal media,as well as on minimal media containing histidine,minimal media containing leucine,and minimal media containing both histidine and leucine.Select for yeast that do not grow on minimal media,do not grow on media supplemented with only histidine or leucine,but do grow on minimal media supplemented with both histidine and leucine.
B) Grow mutagenized yeast on minimal media.Grow yeast on rich media,as well as on minimal media containing histidine,minimal media containing leucine,and minimal media containing both histidine and leucine.Select for yeast that do not grow on rich media,do not grow on media supplemented with only histidine or leucine,but do grow on minimal media supplemented with both histidine and leucine.
C) Grow mutagenized yeast on rich media.Grow yeast on minimal media,as well as on minimal media containing histidine,minimal media containing leucine,and minimal media containing both histidine and leucine.Select for yeast that grow on minimal media,grow on media supplemented with only histidine or leucine,but do not grow on minimal media supplemented with both histidine and leucine.
D) Grow mutagenized yeast on minimal media.Grow yeast on rich media,as well as on minimal media containing histidine,minimal media containing leucine,and minimal media containing both histidine and leucine.Select for yeast that grow on rich media,grow on media supplemented with only histidine or leucine,but do not grow on minimal media supplemented with both histidine and leucine.

E) All of the above
F) B) and D)

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In eukaryotes,mRNA processing involves all of the following events except


A) elongation of the transcript.
B) addition of a 5' cap.
C) addition of a poly A to the 3' end.
D) pre-mRNA splicing.
E) association with the spliceosomE.

F) B) and D)
G) B) and C)

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The 3-nucleotide sequence of an mRNA is called the


A) codon.
B) anticodon.
C) amino acid.
D) transcript.
E) templatE.

F) B) and C)
G) B) and E)

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The genetic code operates on all the following principles except


A) all four of the nucleotide bases must be used.
B) each combination of any three nucleotides can act as a codon.
C) the first nucleotide in every codon is always the same.
D) a particular codon always specifies the same amino aciD.

E) A) and B)
F) B) and D)

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The bond that forms between the newly added amino acid and the previous amino acid on the chain is called a


A) hydrogen bond.
B) hydrophobic bond.
C) hydrophilic bond.
D) phosphodiester bonD.
E) peptide bond.

F) B) and E)
G) D) and E)

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Crick and his colleagues proposed that the genetic code consisted of a series of blocks of information,called _____,each corresponding to an amino acid in the encoded protein.


A) alleles
B) codons
C) DNA
D) polypeptides

E) B) and C)
F) A) and B)

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Why are there only 45 different tRNA anticodons rather than 64 to match each of the mRNA codons?


A) The first nucleotide of a tRNA anticodon allows some flexibility or "wobble."
B) The second nucleotide of a tRNA anticodon allows some flexibility or "wobble."
C) The third nucleotide of a tRNA anticodon allows some flexibility or "wobble."
D) The remaining 19 tRNA anticodons are used for initiation and termination of protein synthesis.

E) A) and D)
F) C) and D)

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