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Gene inactivation is likely to produce


A) pseudogenes.
B) orthologs.
C) paralogs.
D) homologues.

E) A) and B)
F) A) and C)

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Which one of the following statements about horizontal gene transfer is false?


A) Horizontal gene transfer is also called lateral gene transfer.
B) Horizontal gene transfer involves hitchhiking genes from other species.
C) Horizontal gene transfer was common early in life, but is absent today.
D) Gene swapping is evident in the human genome.

E) A) and B)
F) A) and C)

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The entire DNA sequence of a species is called its ________________.

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Recent research has suggested that some pseudogenes and non-protein-coding DNA code for RNAs that affect transcription of coding regions.This suggests that


A) pseudogenes code for proteins.
B) non-protein-coding DNA has no function.
C) non-protein-coding DNA may regulate gene expression.
D) pseudogenes have no function.

E) A) and B)
F) A) and C)

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Choose the correct sequence of events involving allopolyploidy that gave rise to modern tobacco.


A) hybridization, chromosome doubling, duplicate gene loss
B) hybridization, duplicate gene loss, chromosome doubling
C) chromosome doubling, hybridization, duplicate gene loss
D) duplicate gene loss, hybridization, chromosome doubling

E) All of the above
F) A) and B)

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Using the sequencing results for genomes from each of the kingdoms, it is currently possible


A) to explore genetic differences between species very directly, examining DNA changes.
B) to build, from scratch, complex organisms with trans-kingdom genomes.
C) to sequence and build, from scratch, simple organisms with trans-kingdom genomes.
D) to design humans with a variety of inter-kingdom abilities built into their DNA.

E) A) and C)
F) All of the above

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The human genome


A) has no foreign DNA because it is excised by DNase.
B) has a very small amount of foreign DNA, mostly in the end caps (telomeres) of chromosomes.
C) has a lot of foreign DNA, mostly in the end caps (telomeres) of chromosomes.
D) has a lot of foreign DNA scattered throughout the genome, including transposons.

E) A) and C)
F) C) and D)

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What type of genes would be most likely to exhibit different expression patterns between humans and non-human primates, such as gorillas?


A) Genes controlling brain development.
B) Genes controlling mammary gland development.
C) Genes controlling lung development.
D) Genes controlling heart development.

E) A) and B)
F) A) and C)

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Petrels (a flying and diving seabird) are thought to be one of the closest living relatives to penguins.What type of genes would be most likely to exhibit different expression patterns between these species?


A) Genes controlling skeletal development.
B) Genes regulating the digestive tract.
C) Genes regulating salt water tolerance.
D) Genes controlling organ development.

E) B) and C)
F) C) and D)

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Choose the true statement about genome size and gene number in animals.


A) There is a strong correlation between the number of genes and genome size.
B) Much of the extra DNA in humans is in the form of exons.
C) The pufferfish has a larger genome than humans and more genes.
D) Genome size differences depend to a large extent on the amount of retrotransposon DNA present.

E) B) and C)
F) A) and D)

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Some of the olfactory receptor (OR) genes in humans


A) have been inactivated, reducing our olfactory capabilities compared to other primates.
B) have been activated, enhancing our olfactory sense compared to other primates.
C) have duplicated more frequently, resulting in increased paralogs compared to other primates.
D) have been conserved more rigidly, resulting in increased orthologs compared to other primates.

E) None of the above
F) All of the above

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Choose the most influential contributing factor to the reduced sense of smell in humans compared with the other great apes.


A) pseudogenes
B) conservation of synteny
C) aneuploidy
D) one more chromosome in humans compared to the other great apes

E) None of the above
F) A) and D)

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Choose the true statement about the human genome and the tiger pufferfish genomes.


A) Essentially all the human genes have nearly identical counterparts in pufferfish.
B) The order of genes along the chromosomes in both species is essentially identical.
C) Both species have about the same amount of introns and "nonsense" sequences of DNA.
D) About 25% of human genes are unique when compared to the tiger pufferfish genome.

E) A) and D)
F) A) and B)

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Many genes in the human genome are no longer expressed because mutations have introduced stop codons within the coding sequence or transposons have disrupted gene function.These genes are now considered


A) pseudogenes.
B) orthologs.
C) paralogs.
D) homologues.

E) C) and D)
F) B) and D)

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The best explanation for the phenotypic differences between humans and chimps despite the great similarities in their gene-coding sequences is


A) the vast differences in exons between their genomes.
B) the vast differences in the introns between their genomes.
C) the "junk" DNA of humans contains important sequences not present in chimps.
D) differences in gene expression between species.

E) A) and C)
F) A) and D)

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Except in rare cases, genes are usually passed from generation to generation within a species.This process is called:


A) horizontal gene transfer
B) vertical gene transfer
C) transgenesis
D) synteny

E) C) and D)
F) None of the above

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If a gene is found in different groups, it is said to be


A) active.
B) variable.
C) conserved.
D) associational.

E) All of the above
F) A) and D)

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Genes are found in the same order for large stretches of the X chromosome in the rat and mouse genomes, indicating


A) occurence of aneuploidy.
B) formation of pseudogenes.
C) conservation of synteny.
D) conservation of neoteny.

E) All of the above
F) A) and D)

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Over long segments of chromosomes, the linear order of mouse and human genes is preserved.This is called conserved ______________.

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Today, gene swapping between two species is


A) impossible, but it happened frequently in the distant past.
B) infrequent but possible; it happened more often in the distant past.
C) much more frequent compared to in the distant past.
D) only possible if they are in the same family of organisms, such as lions and tigers.

E) None of the above
F) A) and D)

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