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The HIV virus is considered a(n) ______ virus, because after getting integrated into the host cell chromosomes, it does not begin replicating immediately.


A) phage
B) latent
C) transforming
D) benign

E) C) and D)
F) None of the above

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Which class of drugs would be effective against HIV but not against most other pathogenic viruses?


A) Nucleotide analogs that halt replication.
B) Receptor antagonists that block viral entry.
C) Non-nucleoside reverse transcriptase inhibitors that block reverse transcription.
D) Translation inhibitors that stop assembly of viral proteins.

E) None of the above
F) B) and D)

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A doctor's office has run out of the latest flu vaccine, but many patients are asking for it.One of the nurses finds some vials from last year's batch in a refrigerator.Should they be used?


A) Yes, because the preservatives and refrigeration ensure that the vaccine is still fresh.
B) No, because each year the technology to make a good vaccine improves.
C) No, because each year the vaccine is made against different subtypes of the flu virus.
D) Maybe - the vaccine should be mixed in a test tube with the virus to see if it still inactivates it.

E) A) and C)
F) C) and D)

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Most viruses form a capsid around their nucleic acid core.This capsid is composed of


A) proteins.
B) monosaccharides.
C) glycoproteins.
D) lipoproteins.

E) C) and D)
F) B) and D)

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What is the name for parasitic viral DNA that has been integrated into the chromosome of its bacterial host?


A) prophage
B) prophase
C) viroid
D) virion

E) B) and C)
F) None of the above

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A mutation in the gene encoding the integrase enzyme renders the protein non-functional.How would this affect-the HIV infection cycle?


A) The gp120 glycoprotein would not be able to bind the CCR5 receptor.
B) Reverse transcription would not be possible.
C) The viral DNA would not be able to integrate the viral genome into a chromosome.
D) Cutting and assembling the capsid would be halted.

E) C) and D)
F) All of the above

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Viruses can ________ only after they have entered a host cell, and only by using the host's cellular machinery.

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HIV studies revealed that it is closely related to


A) smallpox virus.
B) ebola virus.
C) herpes virus.
D) a chimpanzee virus.

E) All of the above
F) C) and D)

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A layer of lipoprotein and glycoprotein that covers the outer surface of some viruses is the


A) capsid.
B) casing.
C) envelope.
D) membrane.

E) C) and D)
F) B) and D)

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All of the following are part of phage conversion except


A) injection of phage gene into host.
B) transcription and translation of phage gene.
C) induction of phage.
D) expression of phage gene by host.

E) A) and C)
F) A) and D)

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A ____________ can contain DNA or RNA as its genetic material, but not both.

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virus

All of the following are diseases caused by viruses except


A) strep throat.
B) AIDS.
C) polio.
D) small pox.

E) B) and C)
F) A) and D)

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A

Nucleotide analogs are a class of drugs that are highly effective against many types of viruses.They work by halting the replication of viral genes.They are equally effective at stopping the spread of prion diseases.

A) True
B) False

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Tetracycline is effective against viruses because it disrupts the action of the viral ribosomes.

A) True
B) False

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False

What best describes whether a virus is likely to infect a particular cell?


A) Viruses infect the first cells they encounter.
B) If a host cell is weakened, viruses are likely to infect it.
C) A virus will only infect host cells with the correct surface receptors.
D) Viruses only attack epithelial cells, such as the cells lining the lungs.

E) A) and B)
F) All of the above

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The onset of AIDS is often accompanied by


A) a steep drop in T cell numbers.
B) macrophage infection.
C) a positive HIV test.
D) lung infections and other opportunistic infections.

E) None of the above
F) All of the above

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Scientists have demonstrated that the cholera bacteria, Vibrio cholerae, can exist as a rather harmless form or, by phage conversion, can exist as a disease-causing, virulent form.This conversion is caused by


A) the phage entering the cholera bacterium genome and causing the bacterium's cell to lyse.
B) the phage introducing a gene into the bacterium's chromosome that codes for the cholera toxin that can cause death in humans.
C) the phage altering the cell wall of the cholera bacterium that produces a toxin that can cause death in humans.
D) the phage alters the host cell, which permits direct entry of the cholera bacterium into the host cell leading to death in humans.

E) A) and D)
F) C) and D)

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The infection cycle of HIV includes all of the following steps except


A) attachment.
B) entry.
C) replication.
D) immediately killing the host cell.

E) A) and C)
F) A) and B)

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Integrase inhibitors work by:


A) Agglutinating the reverse transcriptase inhibitors
B) Degrading the viral envelope
C) Preventing the incorporation of the viral DNA into the genome
D) Blocking the final viral assembly

E) A) and B)
F) B) and C)

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Gardasil is marketed as a cervical cancer vaccine, but it is actually a human papilloma virus (HPV) vaccine.Why is this done?


A) The virus multiplies more rapidly in cancerous cells.
B) Cancer cells are particularly susceptible to viral infection.
C) Genital warts is a sign of cancer.
D) HPV in the cervical epithelial cells may cause the cells to become cancerous.

E) A) and C)
F) C) and D)

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