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You are a professor supervising first year medical students.One student is examining the adrenal gland of his cadaver."Wow!" he exclaims,"This person must have had an endocrine problem.Their adrenal gland lacks any kind of duct connecting it to the bloodstream.The hormones could only have oozed out." How do you respond?


A) "That makes their adrenal gland similar to an exocrine organ."
B) "Do you see signs of adrenal insufficiency,such as low fat stores or muscle degeneration?"
C) "That's normal.The hormones ooze out and diffuse into nearby capillaries,which is why endocrine glands are sometimes called 'ductless glands'."
D) "Look carefully and you will see the nerves that transport the hormones into the bloodstream."

E) A) and B)
F) B) and D)

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Nonpolar hormones can pass through the intestinal cell membrane without being digested,and therefore can be taken orally.Which of the following hormones are available as pills?


A) insulin and growth hormone
B) thyroid hormone and steroid hormones
C) calcitonin and insulin
D) insulin and steroid hormones
E) calcitonin and thyroid hormone

F) A) and C)
G) A) and E)

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Which of the following features distinguishes all hormones from neurotransmitters?


A) Hormones require large concentrations to have an effect,while neurotransmitters require only low concentrations.
B) A hormone affects reproductive functions,while neurotransmitters control all other processes.
C) Hormones travel via the blood to a target tissue,while neurotransmitters cross the synaptic cleft to a postsynaptic cell.
D) Hormones are steroids,while neurotransmitters are amino acids.

E) B) and D)
F) A) and D)

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Which is the best explanation for how ibuprofen works?


A) It thins the blood to relieve joint pain.
B) It inhibits cyclooxygenase-2,which is needed to produce prostaglandins.
C) It activates cyclooxygenase-2,which then produces more prostaglandins.
D) It down-regulates the production of substance P.
E) It activates cyclooxygenase-2,which promotes healing of tissue.

F) A) and B)
G) A) and C)

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The use of bovine growth hormone (BGH) to increase milk yield in dairy cows is highly controversial.What other hormone is regularly added to milk,yet causes little controversy?


A) vitamin A
B) vitamin D
C) MSG
D) preservatives

E) All of the above
F) None of the above

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Which statement does NOT correctly describe hormones that can directly enter a cell?


A) Steroid hormones can enter directly into cells because of their hydrophobic makeup.
B) Water-soluble hormones can enter directly into cells because of their nonpolar makeup.
C) Steroid hormones dissolve poorly in the plasma and are transported to target cells via special protein carriers.
D) Once these hormones enter a cell,they bind to a cytoplasmic receptor and travel as a complex to the nucleus,or they may bind to the receptor after entering the nucleus.

E) None of the above
F) A) and D)

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Your friend is concerned because although she has never been pregnant,her breasts are producing milk.When she went to the doctor,he sent her to the MRI lab for a brain scan.She was too embarrassed to ask the doctor why.What do you tell her?


A) "They were actually scanning your thyroid gland,not your brain.Are you getting enough iodine in your diet?"
B) "The MRI technician must have mixed up your patient records.He should have done a thoracic scan instead."
C) "LH and FSH from the posterior pituitary stimulate milk production.The doctor wants to rule out excess levels of estrogen in the pituitary stalk."
D) "Prolactin from the anterior pituitary stimulates milk production.The doctor probably wants to rule out a pituitary tumor."

E) All of the above
F) A) and C)

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What is a primary function of growth hormone?


A) initiates stress response
B) raises blood glucose level
C) lowers blood glucose level
D) stimulates bone growth
E) inhibits loss of calcium from bone

F) B) and E)
G) B) and D)

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Which of the following does NOT correctly describe antidiuretic hormone?


A) It regulates water turnover in the mammalian kidney.
B) ADH secretion is stimulated by high blood osmolarity.
C) It ultimately acts to reabsorb more water.
D) It exerts it effects via the cAMP pathway.
E) It does not involve the use of aquaporin molecules.

F) C) and E)
G) D) and E)

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Which of the following hormones regulates metamorphosis and molting in insects?


A) melatonin
B) ecdysone
C) estrogen
D) somatostatin
E) trypsin

F) B) and E)
G) A) and B)

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Some intercellular regulatory molecules that exert only very local effects are called ________ regulators.


A) sympathetic
B) exogeneous
C) merocrine
D) endocrine
E) paracrine

F) C) and E)
G) A) and C)

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Beta-blockers are a class of drugs that target beta-adrenergic receptors,blocking the action of epinephrine and norepinephrine.These drugs are used to treat heart conditions,hypertension,glaucoma,and migraine headaches and are also used off-label to alleviate stage fright in performers.Since the beta-adrenergic receptor is a GPCR,what intracellular event is prevented by the use of a beta-blocker?


A) a protein kinase cascade,initiated by the receptor's intracellular kinase domain
B) release of an activated G protein subunit bound to GTP
C) transport of the receptor-hormone complex into the cell and the nucleus,where it would regulate transcription
D) a protein phosphatase cascade,initiated by the receptor's intracellular phosphatase domain

E) None of the above
F) B) and D)

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Which hormone is secreted by alpha cells of the pancreas in response to hypoglycemia?


A) glucagon
B) insulin
C) glucose
D) cortisol
E) glycogen

F) C) and E)
G) A) and C)

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Choose the hormone that is NOT correctly matched with the endocrine gland that secretes it.


A) adrenal cortex-aldosterone
B) pancreas-insulin
C) pineal gland-melatonin
D) adrenal medulla-cortisol
E) posterior lobe of pituitary gland-oxytocin

F) B) and D)
G) B) and E)

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What hormone stimulates the milk-ejection reflex?


A) antidiuretic hormone
B) oxytocin
C) vasopressin
D) parathyroid hormone
E) aldosterone

F) B) and D)
G) None of the above

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You are studying a disease caused by insufficient levels of a specific peptide hormone,and characterize mutations in several genes that can lead to the disease.Your startup company can only afford to pursue one gene product as a possible therapy.Which would you choose?


A) Gene A - a transcription factor.
B) Gene B - an enzyme that activates the hormone by cleaving its inactive precursor.
C) Gene C - the hormone itself.
D) Gene D - a kinase that acts downstream of the hormone.

E) None of the above
F) A) and C)

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How could you improve your experiment?


A) Apply the hormone to mouse cell culture.
B) Apply the hormone at a concentration of 0.5M.
C) Hydrolyze the hormone before application.
D) Add ATP as a cofactor.

E) A) and B)
F) B) and C)

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When the body's blood glucose level rises above normal,which of the following hormones is produced?


A) glucagon
B) epinephrine
C) insulin
D) norepinephrine
E) prolactin

F) B) and C)
G) A) and E)

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Blood glucose levels must be carefully maintained within a narrow window.What endocrine organ is responsible for this task?


A) pancreas
B) pineal gland
C) pituitary gland
D) parathyroid gland

E) A) and B)
F) B) and C)

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Which hormone lowers blood glucose levels?


A) glucocorticoids
B) epinephrine
C) insulin
D) glucagon
E) melatonin

F) A) and B)
G) B) and E)

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