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A water-soluble hormone binds to its receptor on the plasma membrane.Arrange the events that follow in correct sequence. (1) alpha subunit-GTP complex alters cell activity (2) GTP binds to the alpha subunit replacing GDP (3) G-protein subunits separate from the receptor (4) alpha subunit separates from other two subunits (5) G-protein subunits bind to the receptor


A) 5,2,3,4,1
B) 4,2,1,3,5
C) 5,2,1,4,3
D) 5,4,2,1,3
E) 3,4,1,2,5

F) C) and D)
G) C) and E)

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Which intracellular mediator is directly activated by the binding of a water-soluble hormone to a membrane receptor?


A) cGMP
B) cAMP
C) calmodulin
D) phospholipase C

E) All of the above
F) A) and B)

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Which of the following statements is NOT true?


A) The hypothalamus is important to both the nervous and endocrine systems.
B) Both the nervous and endocrine systems may utilize the same chemical molecule.
C) Some neurons secrete hormones.
D) Both the nervous and endocrine systems respond quickly and are active for a long time.

E) B) and C)
F) A) and B)

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Phosphodiesterase functions


A) as a membrane-bound receptor molecule.
B) to inactivate cyclic AMP.
C) to attach phosphate groups to enzymes.
D) to combine GTP with cyclic AMP.
E) activates cGMP.

F) None of the above
G) B) and E)

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Match the description with the type of receptor model. -membrane channels may be opened or closed


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Given the following list of organic molecules,which includes hormones? 1) nucleic acid derivatives 2) polypeptides 3) steroids 4) proteins


A) 1,3,4
B) 1,2,3
C) 2,3,4
D) 1,2,3,4
E) 1,2,4

F) A) and D)
G) None of the above

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Hormonal secretion can be regulated by


A) the action of a substance other than a hormone.
B) the nervous system.
C) other hormones.
D) All of these choices are correct.
E) None of these choices is correct.

F) A) and E)
G) A) and B)

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When a few intracellular mediator molecules activate several enzymes,and each of these activated enzymes activate still other enzymes,the hormone has initiated


A) a cascade effect.
B) a double loop effect.
C) a protein kinase effect.
D) a cyclic effect.
E) a negative feedback cycle.

F) A) and E)
G) A) and D)

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An intercellular chemical signal that is produced by neurons but functions like a hormone would be called a


A) neuropathogen.
B) neurotransmitter.
C) neurocrine.
D) neurohormone.
E) neurosynthesizer.

F) A) and B)
G) A) and E)

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Which of the following occurs when a hormone binds to a nuclear receptor?


A) activation of cyclic AMP
B) activation of mRNA synthesis
C) increased lipid synthesis by ribosomes
D) opens membrane channels
E) alters membrane permeability

F) None of the above
G) A) and B)

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What type of hormone-receptor action allows insulin to move glucose into cells?


A) activation of cGMP
B) activation of adenylate cyclase
C) direct alteration of intracellular enzymes
D) phosphorylation of intracellular proteins

E) A) and B)
F) A) and C)

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Which of the following events occurs last?


A) IP3 (inositol triphosphate) is produced.
B) Epinephrine combines with membrane-bound receptor on smooth muscle cell.
C) Calmodulin binds to the enzyme that phosphorylates myosin and cross-bridges form.
D) IP3 stimulates Ca2+ release from the endoplasmic reticulum.
E) Ca2+ binds with calmodulin.

F) A) and C)
G) B) and C)

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Which pattern of hormone secretion,represented by epinephrine,can have dramatic changes in its concentration and circulating levels?


A) chronic hormone secretion
B) long-term hormone secretion
C) episodic hormone secretion
D) acute hormone secretion

E) B) and D)
F) A) and C)

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Match the description with the type of receptor model. -messenger RNA synthesis regulated


A) nuclear receptor model
B) membrane-bound receptor model

C) A) and B)
D) undefined

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Hormones are intercellular chemical signals that


A) are secreted into the external environment where they act.
B) affect only non-hormone producing organs or tissues.
C) help coordinate growth,development and reproduction.
D) operate primarily by positive feedback.

E) A) and C)
F) None of the above

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Steroid hormones


A) bind to membrane receptors.
B) diffuse easily through the plasma membrane.
C) act by activating cAMP.
D) are inactivated by phosphodiesterase.
E) are water soluble.

F) C) and D)
G) A) and E)

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Match the chemical signal with the appropriate description. -paracrine


A) chemicals produced by neurons that function as hormones
B) chemicals that act locally on nearby cells
C) chemical secreted by presynaptic terminal
D) influences same cell type from which it is secreted
E) chemical secreted into blood by specialized cells; travels some distance to target tissues

F) A) and E)
G) A) and B)

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Most endocrine glands communicate with their target tissues using _____ signals.


A) frequency-modulated
B) amplitude-modulated
C) pitch-modulated
D) resonance-modulated

E) B) and C)
F) B) and D)

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What type of chemical messenger is released from neurons to activate an adjacent cell?


A) paracrine
B) neurotransmitter
C) autocrine
D) endocrine

E) B) and C)
F) B) and D)

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Which chemical type of hormone has a longer half-life?


A) lipid-soluble
B) protein
C) water-soluble
D) amino acid derivative

E) A) and B)
F) B) and C)

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